IGF1 and sarcoma: Several phase I and II studies were conducted evaluating anti-IGF1 mAbs in relapsed and refractory solid tumors including sarcomas, the largest being a phase II study by the COG that enrolled 116 patients, including 20 with rhabdomyosarcoma, 11 with osteosarcoma, and 10 with synovial sarcoma; there were no objective responses in any of the sarcoma patients (48, 49).