Consequently, patients present with a constellation of physical and neuropsychiatric findings (i.e. musculoskeletal complaints, depression, free-floating anxiety, memory deficits) [6, 7], and in cases of thyroid autoimmunity, formation of anti-bodies to thyroglobulin (Tg) and thyroid peroxidase (TPO) [4]. The gene discussed is TPO; the disease is major depressive disorder.