They found that mice that are heterozygous for an Actn4 transgene but homozygous for UCHL1 KO (K256E-Actn4pod+/UCHL1−/−) exhibited significantly ameliorated albuminuria, glomerulosclerosis, and foot process enfacement at 10 weeks of age. The gene discussed is ACTN4; the disease is glomerulosclerosis.