APP and Alzheimer disease: In addition, it has been reported that mild OS could trigger the amyloid cascade being, therefore, involved in the very early stages of AD: in fact, it causes an alteration of the subcellular compartmentalization of BACE1 (beta-site APP cleaving enzyme 1), an enzyme involved in the β-secretase cleavage of the APP; as a result, the amyloidogenic processing of APP is favoured [46].