Indeed, the administration of PPARγ agonist thiazolidinediones (such as rosiglitazone and pioglitazone) was proven to be protective in transgenic HD mice [158, 159, 165], in an intrastriatal quinolinic acid-induced rat toxin model of HD [166], in 3-nitropropropionic acid-induced murine toxin model of HD [167], and in in vitro HD models [159, 165, 168]. The gene discussed is PPARG; the disease is Huntington disease.