Notably, no indirect or direct signs indicative striatal neuronal degeneration and/or loss were observed in our study [122], which corresponds to the independent observations of Lucas et al. [202], both publications drawing the conclusion that PGC-1α-deficiency per se is not sufficient to evoke HD-like pathology, contrasting to what had previously been suggested. The gene discussed is PPARGC1A; the disease is Huntington disease.