With regard to the common factors associated with HCC prognosis and recurrence, 83 % of the subjects had a single tumor, 65 % of the primary tumors were more than 5 cm in diameter, 58 % of patients had stage III tumors, and 41 % of patients had blood alpha-fetoprotein (AFP) levels greater than 4000 ng/ml. The gene discussed is AFP; the disease is neoplasm.