EZH2 and triple-negative breast carcinoma: Consistent with the requirement for removal of both repressive H3K9 and H3K27 methylation marks, we show that dual inhibition of EHMT2 and EZH2 pharmacologically or by SiRNA is necessary for reactivation of certain genes and induces greater inhibition of cell growth than targeting either HKMT alone in triple negative breast cancer MDA-MB-231 cells.