CD4 and AIDS: Since bone marrow is not only the niche of HSPC, but also the niche of memory CD4 T-cells and other immune cells [11–20, 23, 34–40, 48–58], we will briefly address the restorative effects of antiviral therapy and anti-inflammatory drugs on HSC, memory CD4 T-cells, and the bone marrow niche, elucidating our point of view on how to utilize anti-inflammatory drug, immunotherapy, and multidiscipline approaches towards an HIV eradication and AIDS cure.