The first wave of GWAS was conducted in Europeans and identified a dozen loci, of which 8 T2D susceptibility loci have been replicated across multiple ethnic groups: TCF7L2, SLC30A8, HHEX, CDKAL1, IGF2BP2, CDKN2A/B, PPARG, and KCNJ11 (Cauchi et al., 2007; Lee et al., 2008; Ng et al., 2008; Wu et al., 2008; Hu et al., 2009; Rong et al., 2009; Chauhan et al., 2010; Han et al., 2010). The gene discussed is PPARG; the disease is type 2 diabetes mellitus.