However, markers of immune destruction like islet cell auto-antibodies, auto-antibodies to insulin, GAD65, and tyrosine phosphatases IA-2 and IA-2b and rise in circulating levels of C-peptide help in reasonably accurate diagnosis of T1D and determine their clinical course (Arvan et al., 2012; American Diabetes Association, 2014; Atkinson et al., 2014). Here, INS is linked to type 1 diabetes mellitus.