Conversely, elevated expression levels of RAGE, TLR4 and/or components of the TLR signaling machinery like myeloid differentiation primary response gene 88 (MYD88) by malignant tissues have been correlated with shortened disease-free and overall survival in 2 cohorts of 109 and 123 ovarian carcinoma patients subjected to surgery (195, 196), in a cohort 108 subjects with CRC (193), and amongst 180 individuals with gastric carcinoma (199). This evidence concerns the gene TLR4 and colorectal carcinoma.