PANK1 and tuberculosis: For example, pantothenate kinase (PanK), the enzyme that catalyzes the first, and rate-limiting, step in the conversion of pantothenate (vitamin B5) into CoA (Das et al., 2006), has attracted considerable attention as a TB drug target (Begley et al., 2001; Spry et al., 2008; Moolman et al., 2014).