CARD9 and tinea infection: This spectrum ranges from the benign and localized tinea on the one hand, where the host’s defenses appear to be intact, to the life-threatening systemic infections on the other, as seen in CARD9-deficient (Lanternier et al., 2013) or severely immunocompromised patients [e.g., cirrhotic patients (Marconi et al., 2010)].