APP and Alzheimer disease: Although, the human APP is primarily known for its role in Alzheimer’s Disease (Gorevic et al., 1986), some of the App peptides have antibiotic activity against at least eight common and clinically relevant microorganisms, i.e., Gram-negative, Gram-positive bacteria, and the yeast C. albicans with the latter being the most sensitive (Soscia et al., 2010).