EIF2AK2 and Alzheimer disease: Using animal and cells models, we have shown that PKR is activated by Aβ peptide (8, 53, 55–61) through its activator PACT (56), and this activation plays a role in neuronal death in AD (8, 55, 56), Furthermore, we have shown that the activation of PKR (partly by Aβ) could control the levels of β-secretase (BACE1) in stressed cells.