At present, however, the role of the HSP90-Gα12 in animal models of ADPKD remains to be determined, but there is evidence that Gα12 can directly interact with PC-1 (Yu et al., 2011) and HSP90 can be associated with the cilia (Prodromou et al., 2012). The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.