Early after reperfusion following ischemia, RGS4 competed with downstream effectors for Gαq subunits activated by ANGII to prevent the normal induction of Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) following angiotensin II-stimulated in isolated vascular smooth muscle cells (Pang et al., 2015). This evidence concerns the gene RGS4 and ischemia.