The TNFα levels (4.91 ± 1.85 pg/ml) of Pre-DM subjects in our study are normal, slightly lower than the reported TNFα (~15–20 pg/ml) of eastern Indian Pre-DM population (Dutta et al., 2013) and much lower than T2DM (range from 87 to 112 pg/ml) (Goyal et al., 2012). The gene discussed is TNF; the disease is diabetes mellitus.