In contrast to CNS disease induced by auto-reactive TRM CD8 T cells, disease induced by classic IFNγ-producing pro-inflammatory CD8 T cells demonstrates severe ataxia and lethargy within 7 days, a disease pattern highly similar to those induced by in vitro or Vac-activated MBP-specific CD8 T cells (Huseby et al., 2001a; Sasaki et al., 2014). Here, CD8A is linked to Ataxia.