Studies have shown that CD8 T cells are found in MS plaques—these cells are often oligoclonal, accumulate over time and can outnumber CD4 T cells regardless of the stage of activity or disease (Booss et al., 1983; Traugott et al., 1983; Hauser et al., 1986; Babbe et al., 2000; Lucchinetti et al., 2000; Frohman et al., 2006; Lassmann et al., 2007; Huseby et al., 2012). The gene discussed is CD4; the disease is myeloid sarcoma.