We chose the astrocyte protein GFAP as the target antigen because GFAP expression and GFAP-peptide presentation by MHC class I and II molecules are increased within MS lesions (Nait-Oumesmar et al., 2007; Fissolo et al., 2009; Linker et al., 2009). This evidence concerns the gene GFAP and myeloid sarcoma.