The observation that CD8 T cells are present within gray matter lesions of MS patients (Peterson et al., 2001; Bo et al., 2003; Calabrese et al., 2007; Lassmann et al., 2007; Fisher et al., 2008; Lucchinetti et al., 2011; Ontaneda et al., 2012) inspired us to study astrocyte-specific CD8 T cells. This evidence concerns the gene CD8A and myeloid sarcoma.