The ability of CD8 T cells to regulate CNS autoimmune disease may occur by CD8 T cells targeting activated CD4 T cells through the recognition of peptide displayed on MHC class I and Ib molecules, as well as by secreting IL-10 and other anti-inflammatory soluble mediators (Jiang and Chess, 2006; Goverman, 2009; Kim and Cantor, 2011; Ortega et al., 2013). The gene discussed is CD8A; the disease is autoimmune disease.