CDC42 and Anxiety: Interestingly, changes in miRNA-608 activity on AChE binding sites in the brain (e.g., due to single nucleotide polymorphisms, SNPs) concomittantly raise levels of anxiety and blood pressure in adult mice and humans by decreasing the inhibition of AChE expression, while reducing CDC42 and IL-6 levels, important pro-inflammatory mediators (Hanin et al., 2014).