A great variety of cytokines have also been implicated in the pathogenesis of SLE, amongst others, BAFF/BLyS, TNF-α, IFN-α, IFN-γ, IL-12, IL-23, IL-18, IL-6, IL-10, and IL-17 [82, 83]. This evidence concerns the gene IL10 and systemic lupus erythematosus.