2006, 2008; Hong et al. 2013). It has been reported that sesamin decreases blood glucose, insulin and lipid levels in type 2 diabetic mice (Hong et al. 2013). Sesamin also inhibits NAD(P)H oxidase‐induced O2·− production in the aorta in rats administered deoxycorticosterone acetate and salt (Nakano et al. 2006). Furthermore, a sesamin metabolite (SC‐1; (7α,7′α,8α,8′α)‐3,4‐dihydroxy‐3′,4′‐methylenedioxy‐7,9′:7′,9‐diepoxylignane) strongly inhibited xanthin/xanthine oxidase‐induced O2·− production (Nakai et al. 2003; Nakano et al. 2006, 2008). Here, INS is linked to type 2 diabetes mellitus.