To investigate whether the RHBDD1 expression level in tumours is associated with prognosis, we analysed the correlations between RHBDD1 expression and disease-free survival (DFS) and overall survival (OS) in 539 CRC patients who underwent resection at the Cancer Hospital, Chinese Academy of Medical Sciences, from January 2005 to December 2008. The gene discussed is RHBDD1; the disease is neoplasm.