The results showed that RHBDD1 expression was closely associated with higher pathological tumor-node-metastasis (pTNM) stage (N=539, the χ2 test, P=0.0001), higher pathological node (pN) classification (N=539, the χ2 test, P=0.0002) and lower differentiation (N=539, the χ2 test, P=0.006). Here, RHBDD1 is linked to neoplasm.