FLG and Alzheimer disease: It has been reported recently that ILC2s are present in the skin of patients with AD.16, 25 Given the spontaneous expansion in ILC2 frequency in the skin of filaggrin-deficient mice (Fig 3), we investigated whether ILC2 frequency was altered in the skin of patients with mutations in FLG. We now show that there are increased ILC2 numbers (P = .06) in skin blisters taken from nonlesional skin of patients with FLG mutations5 compared with the skin of FLG WT subjects (Fig 6, A).