In the heart of mice with chronic MI, we noted that both Bcl-2 and LC3B-II protein levels were increased, (Figure 1e), but in cardiomyocytes with acute AR insult, Bcl-2 protein level was decreased, while LC3B-II and beclin-1 were increased (Figure 1f). The gene discussed is BCL2; the disease is myocardial infarction.