Consistent with a role of cGMP/PKG in regulating Wnt/β-catenin signaling as reported previously [21, 22, 31], MY5445 and papaverine reduced β-catenin levels, TCF transcriptional activity, and the expression of survivin in HCT116 colon tumor cells at concentrations that parallel those required for PKG activation (Figure 5A, 5B). Here, HNF4A is linked to colonic neoplasm.