HNF4A and colorectal cancer: We also investigated the potential involvement of Wnt/β-catenin signaling in the antineoplastic activity of ADT-094, given that aberrant up-regulation of this pathway is common in colorectal cancer patients [48, 49] and suppression of β-catenin expression and β-catenin/TCF transcriptional activity has been previously implicated in the anticancer activity of sulindac [12, 14, 20, 31, 50].