In our case and for the first time, we selected the anti-GD2 scFv-mouse IgM clone 126 in combination with 4-1BB considering the importance of this costimulatory molecule to sustain cytotoxic T cell activity [17, 18], to favor CD8-positive T cell expansion during either viral infection or allograft rejection [19] and its crucial role in directing the anti-tumor response in animal models and in humans [20]. The gene discussed is CD40LG; the disease is neoplasm.