Genetic alterations resulting in enhanced telomerase activity have recently been implicated in a variety of bone marrow failure syndromes such as acute myeloid leukemia [7, 17–18] inducing an expansion of undifferentiated myeloid hematopoietic stem cell progenitors, but so far no somatic mutations in either TERT or POT1 genes have been described in acute myeloid leukemia (AML). This evidence concerns the gene TERT and acute myeloid leukemia.