In the promoter region, close to the melanoma and glioblastoma hot spot TERT mutations, there is a SNV rs2853669 (−245 T > C), which minor allele destroy a binding site for the Ets2 transcription factor, with an allele frequency in Europeans of 29% (1000 Genome project, http://www.Ensembl.org) and in the Swedish population of 28.6% (Table 1). The gene discussed is ETS2; the disease is melanoma.