In addition, we did not observe any cleavage of the upstream receptors NOD1 (Additional file 3: Figure S2A) and NOD2 (Additional file 3: Figure S2B), nor other crucial signaling proteins implicated in innate immune response to virus infection, including MAVS (Additional file 3: Figure S2C) and STING (Additional file 3: Figure S2D). This evidence concerns the gene NOD2 and viral infectious disease.