We note that the general concept of ‘cardiocerebral channelopathy’ is further underpinned by several recent reports of cardiac arrhythmia, such as long QT syndrome or Brugada syndrome, in single individuals or kindreds with epilepsy due to mutations in ion channel genes such as KCNH2 (Johnson et al., 2009; Omichi et al., 2010; Zamorano-León et al., 2012; Partemi et al., 2013) and KCNQ1 (Goldman et al., 2009; de Llano et al., 2015). Here, KCNH2 is linked to cardiac rhythm disease.