Considering that p75NTR is not only upregulated in pathological conditions (Nykjaer et al., 2005) but also in impaired GABAergic transmission (Riffault et al., 2014), the sortilin deficiency caused by the p.G171A mutation might also be responsible for defects in neurotransmission, resulting in both the development of tremor and high p75NTR expression. The gene discussed is SORT1; the disease is Tremor.