The LAPTM5 gene encodes for a lysosomal-associated multispanning membrane protein that is known to be associated with spontaneous regression of neuroblastomas, pigmented villonodular synovitis, and lung cancer (Finis et al., 2006; Cortese et al., 2008; Inoue et al., 2009). The gene discussed is LAPTM5; the disease is pigmented villonodular synovitis.