These two SNVs were also highly conserved across different species while the other one reported in European population (ExAC data) and situated in the GRIN2D gene, which encodes a class of ionotropic glutamate receptor and has been associated with schizophrenia susceptibility in the Japanese population (Makino et al., 2005), was not. The gene discussed is GRIN2D; the disease is schizophrenia.