These studies further indicated that there might be mislocalisation of IRS1 in neurons in AD, since there was reduced nuclear staining for serine phosphorylated IRS in neurons with NFTS and distinct labelling of structures that would be expected to be phospho-tau positive, namely NFTS, neuropil threads, neuritic plaques and GVD. The gene discussed is MAPT; the disease is Alzheimer disease.