HDGF and colorectal carcinoma: Based on the above data, our hypothesis is that HDGF binds the HDGF-binding regions in the promoter of β-catenin, which results in β-catenin transcriptional activation and its down-stream genes' expression; activated β-catenin further promotes HDGF expression, so the positive feedback loop of HDGF and β-catenin promotes the proliferation, migration, and invasion of CRC cells.