Critically, we also show that both PRK1 and PRK2, but not PRK3, are essential in mediating TXA2/U46619-induced chromatin remodelling (H3Thr11 phosphorylation) and neoplastic responses (cell proliferation, anchorage independent growth/colony formation, and cell migration) in prostate cancer cells. Here, PKN1 is linked to Familial prostate cancer.