Critically, the interaction was found to be functionally important not only in mediating TXA2-induced migratory responses but also revealed that, similar to that which occurs for the AR, signalling through PRK1 enables the TXA2-TP axis to induce chromatin remodeling (histone H3 Thr11 phosphorylation) in the prostate cancer PC-3 cell line and, in addition, to both mimic and augment androgen-induced responses in the LNCaP cell line [35]. Here, PKN1 is linked to Familial prostate cancer.