EGFR and cancer: Hence, mechanistically, in the context of cancer, it is proposed that TP-mediated RhoA activation plays a critical role in the TXA2-induced tumour cell migration and metastasis while its ability to regulate the PI3′K and ERK cascades, including transactivation of the epidermal growth factor receptor (EGFR), may account for the influence of TXA2 on tumour cell proliferation/mitogenesis [7, 26–29].