Hence, owing to the clear mechanistic and functional differences between the individual PRKs, be it PRK1/PKNα, PRK2/PKNγ and PRK3/PKNβ, combined with the increasing recognition of the importance of the TXA2-TP axis in various cancers, it was deemed imperative to investigate whether TPα and/or TPβ might also associate with and, thereby, regulate signalling by PRK2 or PRK3. Here, PKN1 is linked to cancer.