Hence, focusing on the setting of prostate cancer, the aim of this study was to investigate whether TPα and/or TPβ might associate with and regulate the activity, including neoplastic responses, through PRK2/PKNγ and PRK3/PKNβ, AGC kinases that like PRK1/PKNα act downstream of RhoA and PI3′K/PDK1 oncogenic signalling. This evidence concerns the gene RHOA and Familial prostate cancer.