PKN2 and Familial prostate cancer: From a mechanistic point of view, phosphorylation of H3Thr11 by PRK1 and/or by the related PRK2 accelerates the demethylation of histone 3 at lysine 9 (H3K9) by the de-methylases JMJD2C and lysine specific de-methylase (LSD) 1, thereby promoting AR-dependent gene expression and cellular growth and migration in prostate cancer [47, 53, 54].