PKN1 and Familial prostate cancer: Of crucial importance to the current study is that in response to receptor stimulation, activation of both PRK1 and PRK2 are involved in H3Thr11 phosphorylation, cell proliferation/migration in PC-3 cells, thereby providing evidence for the additional role of PRK2 in mediating TXA2-induced chromatin remodelling and malignant growth/metastasis in prostate cancer.