As stated, PRK1/PKNα, along with PRK2/PKNγ and PRK3/PKNβ, are members of a family of structurally related, yet functionally distinct Ser/Thr AGC kinases which, like PRK1, are strongly implicated in tumour promotion including within but not limited to the prostate [42, 43, 46]. This evidence concerns the gene PKN2 and neoplasm.