RHOA and Familial prostate cancer: Therefore, given the increasing evidence of the link between elevated TXA2 signalling and TP expression with various cancers including, but not limited to prostate cancer, coupled with the recognized role of the Gα12-mediated RhoA/PRK1 signalling cascade in cancer, discovery of a direct, functional interaction between TPα and TPβ with PRK1 [35] provided an additional, previously unknown, mechanistic explanation for the “link between the COX-1/2 derived metabolite TXA2 and certain prevalent cancers”.