Immunofluorescence studies revealed, more specifically, that in the tumor reactive stroma, LIF was expressed by inflammatory cells (CD45 positive), likely including macrophages, lymphocytes and neutrophils as evaluated by immunoperoxidase, and CAF (α-smooth muscle actin (α-SMA) positive) (Figure 1G, 1H). The gene discussed is PTPRC; the disease is neoplasm.