Indeed, it has been reported that SDF-1/CXCR4 promotes EMT and progression of colorectal cancer (Hu et al., 2014), oral squamous cell carcinoma, (Onoue et al., 2006), hepatocellular carcinoma (Li et al., 2014), and pancreatic cancer cells (Li et al., 2012). This evidence concerns the gene CXCR4 and oral cavity squamous cell carcinoma.