Reports on estradiol and FSH variability and risk of depression during the MT have been both positive (Freeman et al. 2004a; Freeman et al. 2006; Freeman et al. 2014) and negative (Schmidt et al. 2004; Bromberger et al. 2010; Freeman et al. 2014) and have employed differing ways of assessing variability. Here, BRD2 is linked to depressive disorder.