HMGA1 and type 2 diabetes mellitus: However, although an impact of the HMGA1 rs146052672 variant on risk of T2D is supported in this meta-analysis, biological evidence for this association is still lacking; while reductions in both HMGA1 mRNA and protein expression were reported in both blood monocytes and transformed lymphoblasts obtained from diabetic patients carrying the rs146052672 variant [9], this finding was partially challenged by examining HMGA1 mRNA expression only in subcutaneous fat of healthy Scandinavian subjects with the variant [22], and by bioinformatic analysis on rs146052672 [24].