TCF7L2 and type 2 diabetes mellitus: Considering the resulting strength of association with the disease, it was interesting to note that the HMGA1 rs146052672 variant represented one of the major genetic risk factor for T2D yet described, with an odds similar or even higher (OR = 1.63) than that seen with the TCF7L2 risk alleles (OR = 1.31–1.71) [5].