Results from meta-analyses restricted to studies that used TaqMan allelic discrimination to analyze HMGA1 mutations, showed that the rs146052672 variant genotype had an overall statistically significant effect on increasing the risk of T2D (OR 1.37; 95% CI 1.22, 1.54; P < 0.001), and low heterogeneity (I2 = 43.2%, Q = 10.6, df = 6, P = 0.103) after the exclusion of one study (22) for which genotyping was by HRM (Fig 3E). Here, HMGA1 is linked to type 2 diabetes mellitus.