All measured facets of MAIT cell cytotoxic potential examined were impaired in chronic HIV-1 infection, including reduction in the levels of MAIT cells expressing CD107a+GrzAlo (p = 0.0006), CD107a+GrzB+ (p<0.0001), and CD107a+Prf+ (p = 0.0036) phenotypes in response to bacteria (Fig 5B and 5C). Here, LAMP1 is linked to HIV-1 infection.