As shown in Figure 3, co-treatment with anti-PD-L1, anti-PD-L2 or anti-CD86 antibodies abrogated the effect of these ligands on AMG 330-induced cytotoxicity, further supporting the notion that the redirection of T cells toward AML cells is influenced by the expression of T-cell ligands. This evidence concerns the gene CD86 and acute myeloid leukemia.