In addition, using the Δex8 mice in a mouse model harboring the oncogenic ras allele N-Ras-G12D specifically expressed in hematopoietic cells, enhanced hematopoietic tumorigenesis was observed which supported the notion that MK5/PRAK functions as a tumor suppressor in multiple types of cancers [12]. The gene discussed is MAPKAPK5; the disease is neoplasm.