As expected there appears to be a saturable effect of CCT245737 dose on antitumor activity with the greatest effect occurring at around 100mg/kg p.o. At doses up to 50mg/kg p.o. CCT245737 there was a steep increase in the effects of this CHK1 inhibitor on the tumor growth delay response to gemcitabine indicating that low doses of CCT245737 may still have marked therapeutic activity in this combination. This evidence concerns the gene CHEK1 and neoplasm.