When considering glioma patients as one group irrespective of histological grade, the increased expression of 15 genes (CENPA, DLG7, PBK, FILIP1L, CDC6, MCC, KIF15, MPP6, KIF18A, EZH2, DEPDC1, HMMR, P2RY5, FAM118A, and FNDC3B) correlated with the least favorable survival (Supplementary Figure S6A). This evidence concerns the gene HMMR and central nervous system cancer.