In contrast, the pathologic status ameliorated modestly in CCl4 control group, with a shrinkage in α-SMA immunopositive area and collagen deposition, after spontaneous recovery for two weeks, yet inferior to the therapeutic effects of r-sHSA, which also manifested the potency of r-sHSA on fibrosis reversal. The gene discussed is ACTA1; the disease is fibrosis.