A direct link between CXCL12/CXCR4 upregulation and loss of dopaminergic neurons was provided in an animal model of degeneration of the nigrostriatal system following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration, a well-recognized model of PD [18]. The gene discussed is CXCR4; the disease is Parkinson disease.