Neutralization of soluble TNF signaling in vivo with dominant-negative TNF inhibitor XENP345 (a PEGylated version of the TNF variant A145R/I97T) abrogated in 50% the dopaminergic neuronal degeneration in an experimental model of PD induced by striatal injection of the oxidative neurotoxin 6-hydroxydopamine (6-OHDA) [17]. This evidence concerns the gene TNF and Parkinson disease.