Obesity surgery have shown promising and superior results with respect to metabolic control, weight control and the need for medications, by creating a reduced insulin demand and increased insulin activity (Sjöström et al. 2014; Halperin et al. 2014; Aminian et al. 2014; Rubino et al. 2009; Ghiassi et al. 2012; Chiapaikeo et al. 2014). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.