Thus, the current study was conducted to investigate the coagulation and fibrinolysis indicators protein C, protein S, antithrombin-III, tissue factor pathway inhibitor (TFPI), plasminogen activator inhibitor-1 levels (PAI-1), and placental malaria infection in central Sudan, so as to add to the researches on malaria during pregnancy in Sudan [6–9, 15, 16]. Here, TFPI is linked to malaria.