SERPINC1 and hyperinsulinemic hypoglycemia, familial, 4: Systemic causes are prothrombotic states secondary to genetic coagulopathies like protein C and S deficiency, prothrombin gene mutation [3], antithrombin III deficiency, factor V Leiden mutation, and hyperhomocysteinemia or acquired causes like contraceptive use [4], recent pregnancy, antiphospholipid syndrome, myeloproliferative disorders, and paroxysmal nocturnal hemoglobinuria.