It may cause endothelial dysfunction and cause an afferent renal arteriolopathy and tubulointerstitial fibrosis in the kidney by activating the renin-angiotensin-aldosterone system [16], activate various inflammatory transcription factors [17], and induce systemic cytokine production such as tumor necrosis factor alpha [18] and local expression of chemokines such as monocyte chemotactic protein 1 in the kidney and cyclooxygenase 2 (COX-2) in blood vessels [19]. The gene discussed is PTGS2; the disease is endothelial dysfunction.