Besides that, N-trans-feruloyltyramine (48), which was a phenylpropanoid isolated from the methanolic extract of the seeds of C. odorata [18], may be another constituent that is responsible for the suppression of melanogenesis as this compound has been reported to show more potent inhibitory activity on the expression of tyrosinase protein (an important enzyme in melanin biosynthesis) in mouse B16 melanoma cells than the kojic acid (a tyrosinase inhibitor) [92]. The gene discussed is TYR; the disease is melanoma.