Moreover, recent studies have demonstrated that Nectin-2 is highly expressed in epithelial malignancies and correlates with high malignancy, fast progression, and/or poor prognosis of human breast cancer [14, 15], ovarian cancer [15], gallbladder cancer [16], and the invasive squamous carcinomas of the human uterine cervix [17]. This evidence concerns the gene NECTIN2 and gallbladder cancer.