NECTIN2 and metastatic malignant neoplasm in the lymph nodes: The percentage of positive Nectin-2 and DDX3 expression was significantly higher in PDAC cases with poor differentiation, invasion to surrounding tissues and organs, lymph node metastasis, and TNM stages III and IV disease than in cases with well differentiated tumor, no invasion, no lymph node metastasis, and TNM stages I and II disease (P < 0.05 or P < 0.01) (Table 2).