Since inflammatory markers including interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-α) are implicated in depression and mood disorders,13,14 and inflammatory stimuli can cause transient mood disturbances in healthy individuals,15 a systemic inflammatory process may underlie the association of sedentary time with mood. The gene discussed is CRP; the disease is major depressive disorder.